1 The following adverse reactions happened in at least five% of Depakote-addressed clients and at an equal or higher incidence for placebo than for Depakote: flu syndrome and pharyngitis.
Start defects may well happen even in little ones born to Ladies that are not taking any medicines and do not need other risk aspects.
Considering the fact that clients ended up also taken care of with other antiepilepsy drugs, it is actually impossible, usually, to determine no matter if the next adverse reactions is often ascribed to Depakote alone, or the combination of Depakote and other antiepilepsy medicines.
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If this SPL has inactivated NDCs listed with the FDA initiated compliance motion, they will be specified as a result.
bleeding problems. Simply call your Health care provider if you have any indications of bleeding, which includes: bruising or purple or purple places on your skin
1.two Epilepsy Depakote is indicated as monotherapy and adjunctive therapy within the cure of people with complex partial seizures that come about possibly in isolation or in Affiliation with other sorts of seizures. Depakote is usually indicated for use as sole and adjunctive therapy inside the cure of straightforward and complicated absence seizures, and adjunctively in clients with numerous seizure sorts that include absence seizures.
Really serious skin reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis) happen to be reported with concomitant lamotrigine and valproate administration. See lamotrigine package insert for aspects on lamotrigine dosing with concomitant valproate administration.
The concomitant usage of valproate and clonazepam may possibly induce absence status in sufferers having a heritage of absence variety seizures.
Tend not to give Depakote to Others, even though they've exactly the same signs and symptoms that you've. It may hurt them. You may question your pharmacist or healthcare service provider for information about Depakote that may be prepared for wellness experts.
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Considering the fact that patients were being titrated off An additional antiepilepsy drug through the very first part of the trial, it truly is not possible, in many instances, to determine whether the following adverse reactions is usually ascribed to Depakote by itself, or the combination of valproate and other antiepilepsy drugs.
Start Defects and Reduced IQ Inform pregnant Gals and women of childbearing prospective (together with girls starting the onset of puberty) that use of valproate for the duration of pregnancy improves website the risk of delivery defects, diminished IQ, and neurodevelopmental disorders in young children who were being uncovered in utero. Recommend Ladies to work with efficient contraception although getting valproate.
Suicidal Imagining and Behavior Counsel sufferers, their caregivers, and people that AEDs, which includes Depakote, may well boost the chance of suicidal views and behavior and also to be notify with the emergence or worsening of signs of despair, any unusual adjustments in temper or actions, or maybe the emergence of suicidal thoughts, conduct, or ideas about self-damage.